Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model

摘要

a AVP-exposed adult females exhibited decreased post-training performance on the rotarod procedural learning task (p = 0.048), while (d) male rotarod learning was unchanged by AVP status. b Trend-significant working memory deficits, as measured by spontaneous alternations on the Y-maze, also occurred in AVP-exposed female (p = 0.079), but not male (e), offspring. c While AVP-exposed female did not exhibit anxiety-like behavior changes, f AVP-exposed male offspring spent significantly decreased time on the open arm of the elevated plus maze (p = 0.0019). g Social preference was significantly (p = 0.018) increased in AVP-exposed male offspring, while (h) total interactions were unchanged. i Offspring from both conditions had significantly more interactions with the social cup than with the empty cup [main effect of cup type by two-way ANOVA p < 0.0001, F1,44 = 19.31], while (j) time spent at each cup did not differ by condition. #p < 0.0001 by two-way ANOVA, *p < 0.05, **p < 0.005 per two-sample t-test, error bars represent SEM. 4 litters per condition, 1–6 offspring per sex per litter.