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Visible Lights Combined with Photosensitizing Compounds Are Effective against

机译:与光敏化合物相结合的可见光是有效的

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摘要

Fungal infections are increasing in prevalence worldwide, especially in immunocompromised individuals. Given the emergence of drug-resistant fungi and the fact that there are only three major classes of antifungal drugs available to treat invasive fungal infections, there is a need to develop alternative therapeutic strategies effective against fungal infections. Candida albicans is a commensal of the human microbiota that is also one of the most common fungal pathogens isolated from clinical settings. C. albicans possesses several virulence traits that contribute to its pathogenicity, including the ability to form drug-resistant biofilms, which can make C. albicans infections particularly challenging to treat. Here, we explored red, green, and blue visible lights alone and in combination with common photosensitizing compounds for their efficacies at inhibiting and disrupting C. albicans biofilms. We found that blue light inhibited biofilm formation and disrupted mature biofilms on its own and that the addition of photosensitizing compounds improved its antibiofilm potential. Red and green lights, however, inhibited biofilm formation only in combination with photosensitizing compounds but had no effects on disrupting mature biofilms. Taken together, these results suggest that photodynamic therapy may be an effective non-drug treatment for fungal biofilm infections that is worthy of further exploration.
机译:真菌感染在全世界的患病率越来越大,特别是免疫因素。鉴于耐药真菌的出现以及只有三种主要类别的抗真菌药物可治疗侵袭性真菌感染,需要开发有效针对真菌感染的替代治疗策略。念珠菌白醛人是人类微生物群的共生,也是从临床环境中分离的最常见的真菌病原体之一。 C. albicans拥有几种有毒力的特征,其致力于其致病性,包括形成耐药性生物膜的能力,这可以使C. albicans感染尤其挑战治疗。在这里,我们单独探索红色,绿色和蓝色可见光,并结合普通的光敏化合物,用于抑制和破坏C. albicans Biofilms的效果。我们发现蓝光抑制生物膜形成并自身破坏成熟生物膜,并加入光敏化合物改善其抗抗膜势。然而,红色和绿灯仅抑制生物膜形成,仅与光敏化合物组合,但对破坏成熟生物膜没有影响。总之,这些结果表明,光动力治疗可能是对真菌生物膜感染的有效非药物治疗,这是值得进一步的探索的。

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