Plasmonic Nanocomposite Implants for Interstitial Thermotherapy: Experimental and Computational Analysis

摘要

The ferromagnetic implant (thermoseeds) technique offers desirable features for interstitial thermotherapy. However, its efficacy has been reported to be limited by issues that are related to the properties of the metal alloys that are used to fabricate them and the high number of thermoseeds needed to achieve therapeutic temperature levels. Here, we present the results of a combination of experimental and computational analysis of plasmonic nanocomposite implants (photoseeds)—a combination of Au nanoparticles (NPs) and poly-dimethylsiloxane (PDMS)—as a model material. We performed structural and optical characterization of the Au NPs and repared Au-PDMS nanocomposites, followed by an elucidation of the heat generation capabilities of the Au-PDMS photoseeds in aqueous solution and in-vitro cancer cell suspension. Based on the experimental results, we developed a three-dimensional (3D) finite element method (FEM) model to predict in-vivo thermal damage profiles in breast tissue. The optical absorbance of the Au-PDMS photoseeds were increasing with the concentration of Au NPs. The photothermal measurements and the in-vivo predictions showed that the photothermal properties of the photoseeds, characteristics of the laser sources, and the duration of heating can be tuned to achieve therapeutic temperature levels under in-vitro and in-vivo conditions. Collectively, the results demonstrate the feasibility of using photoseeds for interstitial thermotherapy.