Local Delivery of Single Dose Intra Epiphyseal Bisphosphonates to Prevent the Progression of Legg-Calve-Perthes Disease – Case Series

摘要

Legg-Calve´-Perthes disease (LCPD) or avascular necrosis of the capital epiphysis is an idiopathic disease characterized by interruption of the blood supply to the capital femoral epiphysis resulting in necrosis of the epiphysis. There are a variety of treatment modalities such as containment with braces early in disease to surgical procedures for children presenting late in their age group. The newer modalities of treatment are intravenous bisphosphonates, bone morphogenic protein in clinical subjects.