From Multiple Daily Injections to Hybrid Closed-Loop System in Ten Days Utilizing a Structured Initiation Protocol

摘要

The pivotal studies in MiniMed 670G Hybrid Closed Loop (HCL) system1,2 included participants experienced with insulin pump therapy, assuming that the success of HCL systems depends on prior use of technology. However, there is no evidence for the superior glycemic control achieved by patients with prior experience with advanced technologies over those on multiple daily injections (MDI). For this end, the following standardized protocol to initiate HCL system in individuals on MDI was created: two days, HCL system assessment; five days, HCL system training (two-hour sessions in five consecutive days with groups of three to five participants); three days, Manual Mode use of HCL system, cumulating in ten days from MDI to Auto Mode activation.