4CPS-156 A rare case and an effective drug therapy: off-label use of tacrolimus in a paediatric dysimmune disease

摘要

A 7 month child with an unremarkable previous medical history presented with a history of 18 days of severe secretory diarrhoea. Clinical and histological features were consistent with autoimmune enteropathy. The patient could not tolerate foods, and was started on total parental nutrition (TPN) and i.v. Methylprednisolone, without substantial clinical improvement. Confirmed resistance to traditional therapy and consulted hospital pharmacists. The use of tacrolimus was identified as the best option.