4CPS-086 Proposal to darunavir (drv) the least trough plasma level (tpl) cut-off to estimate plasma hiv viral load (hvl) equal or less than 20 copies/ml

摘要

Darunavir (DRV) is a high genetic barrier protease inhibitor, which when it is combined with a booster drug such as ritonavir or cobicistat, has shown high effectiveness in wild types such as resistant strains of HIV. The lack of conclusive population studies has determined a consensual cut-off level using the IC50, which in its wild type is 55 mcg/l and in resistant strains is 550 mcg/l.