Night Watch on the Titanic: Detecting Early Signs ofEpileptogenesis in Alzheimer Disease

摘要

Aberrant cortical network excitability is an inextricable feature ofAlzheimer disease (AD) that can negatively impact memory andaccelerate cognitive decline. Surface electroencephalogram spikes andintracranial recordings of nocturnal silent seizures in human AD,coupled with the abnormal neural synchrony that precedes developmentof behavioral seizures in mouse AD models, build the case forepileptogenesis as an early therapeutic target for AD. Since mostindividuals with AD do not develop overt seizures, leveragingfunctional biomarkers of epilepsy risk to stratify a heterogeneous ADpatient population for treatment is research priority for successfulclinical trial design. Who will benefit from antiseizureinterventions, which one, and when should it begin?