Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

摘要

a Pie chart representing protein altering variations in ACE2 by allele count and source. b Log base 10 pseudo count adjusted (+1) observed ACE2 allele counts of mutants predicted to impact S-protein binding. Singletons are marked with a ^ and direct S-protein contact residues are underlined. c ACE2 protein domain showing positions with polymorphisms that can alter SARS-CoV-2 S-protein binding. Recurrent polymorphisms (n > 1) that were predicted to not impact S-protein binding are shown in light grey. Residues within the ACE2 peptidase domain (PD) known to interact with viral S-protein are shown as red vertical lines within the peptidase domain in the ACE2 diagram. d Multiple sequence alignment of the S-protein interacting ACE2 sequence from indicated species. ACE2 NxT/S glycosylation motif disrupted in dog, rat, palm civet, and several bat ACE2 is highlighted in red. ACE2 residues that mediate contact with NL63-CoV, SARS-CoV and SARS-CoV-2 are shown as blue, green and orange bars, respectively.