Water orientation and dynamics in the closed and open influenza B virus M2 proton channels

摘要

a Closed channel with the His19 and His27 tetrads in the 0 and +1 charge states, respectively, to mimic their protonation states at high pH. b Open channel with both His19 and His27 tetrads in the +4 charge state to mimic their protonation states at low pH. For clarity, only three out of four helices are shown. Pore-lining residues Leu8, Ser12, Ser16, His19, Trp23, and His27 are shown as sticks. Water in the channel lumen is shown as sticks while water outside the channel is shown as lines.