Altered iron and myelin in premanifest Huntingtons Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

摘要

Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evidence of subtle neurodegeneration. Here, we use novel imaging techniques to determine whether macro- and micro-structural changes can be detected across the whole-brain in the same cohort.