Prospective Association of Novel Metabolic Indices with Metabolic Syndrome in Middle-Aged and Elderly Chinese

摘要

Metabolic syndrome (MS) refers to the metabolic disorders of proteins, fat and carbohydrates that represent risk factors for cardiovascular disease, diabetes and cancer. The prevalence of MS is increasing worldwide due to deteriorating lifestyles, current statistic estimates suggest that one-quarter of the global population, more than 1 billion people, has MS.1 Prevention of MS is an important public health objective as it will reduce of the future societal burden of diabetes and cardiovascular disease. Recently, novel metabolic indices combining both anthropometric and lipid measures were coming out as estimators of visceral adiposity dysfunction and lipid overaccumulation. These new indices, including visceral adiposity index (VAI), lipid accumulation product (LAP) and the product of triacylglycerol and glucose (TyG), have been suggested as early markers of insulin resistance.2 Researchers have highlighted that these new indices are more sensitive indicator of diabetes compared to the traditional adiposity markers (such as BMI and WC), although it remains disputed due to the difference between diverse regions.3,4 Additional, TyG is a novel candidate to predict chronic kidney diseases,5 while LAP index reported to show the highest ability to predict insulin resistance and subclinical vascular damage.6 Accumulating evidence also has suggested that the three parameters have been regarded as simple and novel clinical markers of MS, but they are all cross-sectional.7–9 Hence, a comprehensive consensus has not been reached about the best indices for evaluating the status and risk of MS. It is important to find simple and reliable indicators for easy prediction of patients with MS in clinical settings. We therefore studied the associations of different novel metabolic indices with incident MS among women and men from the population-based study.