Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities superficial trunk and retroperitoneum

摘要

Immunohistochemical expression of IL4Rα and IL13Rα1 in soft-tissue sarcomas and statistical analysis. a Immunohistochemical expression of IL4Rα and IL13Rα1 in various histologic types of soft-tissue sarcomas. IL4Rα and IL13Rα1are expressed in both the cytoplasm and nuclei of tumor cells. Original magnification: × 400. b Receiver operating characteristic curve analysis to determine cut-off points for the expression of nuclear IL4Rα (nIL4Rα, empty arrow), cytoplasmic IL4Rα (cIL4Rα, empty arrowhead), nuclear IL13Rα1 (nIL13Rα1, black arrow), and cytoplasmic IL13Rα1 (cIL13Rα1, black arrowhead). The cut-off points indicate the point of highest area under the curve (AUC) to predict the death of soft-tissue sarcoma patients. AS; angiosarcoma, ES; Ewing sarcoma, EpiS; Epithelioid sarcoma, FS; fibrosarcoma, LMS; leiomyosarcoma, MPNST; malignant peripheral nerve sheath tumor, MyFS; myxofibrosarcoma, SS; synovial sarcoma, US; undifferentiated sarcoma