Calcipotriol/Betamethasone Dipropionate Foam Inhibits Th17 Cytokine Secretion and Improves Epidermal Barrier Markers in a Human Th17 Skin Inflammation Model

摘要

Effect of Cal/BD foam and CP cream on T-helper 17 and IL-17C cytokine levels. Secreted cytokine levels of IL-17A (a), IL-17AF (b), IL-17F (c), IL-17C (d) and IL-22 (e) in culture supernatants of treated and control InflammaSkin® and NativeSkin® models from four donors (each donor with duplicate samples per treatment group). Protein levels (mean ± SEM) are calculated as percentage (%) of the InflammaSkin control. One-way analysis of variance, followed by Tukey’s multiple comparison test, was used to compare effects between treatment groups. Asterisks indicate significant difference at **P < 0.01; ***P < 0.001; ÷  indicates no treatment. Cal Calcipotriol, Cal/BD fixed-dose combination of calcipotriol/betamethasone dipropionate, CP clobetasol propionate, IL interleukin, SEM standard error of the mean