A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia

机译：抗BCMA汽车T细胞疗法在复发/难治多骨髓瘤和血浆细胞白血病中研究抗BCMA汽车T细胞疗法研究

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摘要

Relapsed/refractory (R/R) multiple myeloma (MM) patients and primary plasma cell leukemia (PCL) have an unfavorable prognosis and no effective treatment. This study was designed to assess the safety and preliminary efficacy of a novel anti‐B‐cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell in R/R MM and PCL.

机译：复发/难治性（R / R）多发性骨髓瘤（mm）患者和初级血浆细胞白血病（PCL）具有不利的预后和无效治疗。本研究旨在评估一种新的抗B细胞成熟抗原（BCMA）嵌合抗原受体（CAR）T细胞在R / R mm和PCL中的安全性和初步疗效。

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期刊名称 Clinical and Translational Medicine
作者
Chunrui Li; Wenyue Cao; Yimei Que; Qiuxiang Wang; Yi Xiao; Chaojiang Gu; Di Wang; Jue Wang; Lijun Jiang; Hao Xu; Jinhuan Xu; Xiaoxi Zhou; Zhenya Hong; Na Wang; Liang Huang; Shangkun Zhang; Liting Chen; Xia Mao; Min Xiao; Wei Zhang; Li Meng; Yang Cao; Tongcun Zhang; Jian Li; Jianfeng Zhou;
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年(卷),期 2021(11),3
年度 2021
页码 e346
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
anti‐BCMA CAR T cell; multiple myeloma; plasma cell leukemia; relapsed/refractory;

机译：抗BCMA CAR T细胞;多发性骨髓瘤;血浆细胞白血病;复发/难治;
入库时间 2022-08-21 11:57:23

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专利

1. A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia [J] . Chunrui Li, Wenyue Cao, Yimei Que, Clinical and Translational Medicine . 2021,第3期

机译：抗BCMA汽车T细胞疗法在复发/难治多骨髓瘤和血浆细胞白血病中研究抗BCMA汽车T细胞疗法研究
2. JCARH125, Anti-BCMA CAR T-cell Therapy for Relapsed/Refractory Multiple Myeloma: Initial Proof of Concept Results from a Phase 1/2 Multicenter Study (EVOLVE) [J] . Mailankody Sham, Htut Myo, Lee Kelvin P., Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：JCARH125，抗BCMA汽车T细胞治疗复发/难治性多发性骨髓瘤：初始证明概念来自阶段1/2多中心研究（Evolve）
3. A phase 1, multicenter study evaluating the safety and efficacy of KITE-585, an autologous anti-BCMA CAR T-cell therapy, in patients with relapsed/refractory multiple myeloma [J] . Robert F Cornell, Jinghui Dong, John B Le Gall, American Journal of Cancer Research . 2021,第6期

机译：一期，多中心研究评估KITE-585的安全性和功效，复发/难治性多发性骨髓瘤患者的自体抗BCMA汽车T细胞疗法
4. PHOSPHOLIPIDS' SERA AND MONONUCLEAR CELLS IN ACUTE LEUKEMIA, MALIGNANT LYMPHOMA AND MULTIPLE MYELOMA-EVALUATION BY ~(31)P MRS IN VITRO [C] . M. KULISZKIEWICZ-JANUS, B. BACZYNSKI NATO advanced research workshop on magnetic resonance in colloid and interface science . 2002

机译：磷脂的血清和单核细胞在急性白血病，恶性淋巴瘤和多发性骨髓瘤 - 评估中由〜（31）PRS体外
5. A Phase 1/2 Study of Ixazomib as a Replacement for Bortezomib or Carfilzomib for Multiple Myeloma Patients Recently Relapsed or Refractory to Their Last Combination Regimen Containing Either Bortezomib or Carfilzomib [D] . Forouzan, Eli. 2020

机译：Ixazomib的第1/2期作为替代品髓鞘或胭脂瘤患者的替代品的替代物，最近对含有Bortezomib或Carfilzomib的最后组合方案复发或难治
6. Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature [O] . Ying Qian, Zijun Qian, Xiujie Zhao, 2021

机译：成功处理复发/难治性髓外骨髓瘤与抗BCMA Car-T细胞疗法其次是Haploidentical造血干细胞移植：案例报告和对当代文学的审查
7. A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia [O] . Chunrui Li, Wenyue Cao, Yimei Que, 2021

机译：抗BCMA汽车T细胞疗法在复发/难治多骨髓瘤和血浆细胞白血病中研究抗BCMA汽车T细胞疗法研究
8. Innate Anti-Breast Cancer Activity of -T cells: A Novel Biological and Clinical Approach to the Treatment of Relapsed or Refractory Breast Cancer [R] . Lopez, R. D. 2009

机译：T细胞的先天性抗乳腺癌活性：一种治疗复发或难治性乳腺癌的新型生物和临床方法

A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia

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