Syphilis, caused by Treponema pallidum subsp pallidum (T. pallidum), is a chronic, systemic human disease transmitted through sexual contact. The incidence and prevalence of syphilis is still high in China.[1] To guide the prevention measures and management of this disease, we renew the guidelines on diagnosis and treatment of syphilis [Supplementary file]. Manifestations and diagnosis of all stages of syphilis are presented in Table Table1,1, and management in Table Table22.
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