Cover Feature: Chromatography‐Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur (ChemistryOpen 1/2021)

摘要

The Cover Feature shows the application of aqueous polysulfide solutions in the chromatography‐free multicomponent synthesis of thioureas. We have used a large pool of bases to cleave the octasulfur ring generating water‐soluble, zwitterionic polsulfide chains. Using these aqueous solutions as sulfurating agents, we were able to omit the otherwise mandatory chromatography to separate the organic products from the excess of sulfur. The methodology has been validated in a wide range of synthesis scenarios highlighting challenging biaryl derivatives and the marketed drug, thiocarlide. More information can be found in the Full Paper by András Gy. Németh et al.