CMIP is a negative regulator of T cell signaling

摘要

Expression of CMIP in MCNS. a RT-qPCR to determine CMIP expression in healthy subjects (n = 10) and MCNS patients (n = 10) at relapse and in steroid-free remission. The data are quantified as the fold-change in induction relative to the control subject (mean with SEM, *p = 0.0156, Mann-Whitney test). b Western blot analysis of CMIP expression in the PBMCs of MCNS patients in relapse and remission. HEK cells transfected with recombinant human CMIP served as a positive control. c Confocal microscopy analysis of Tcells isolated by negative immunoselection and double-labeled with CMIP (green) and CD3 (red) antibodies. Left panel: control: healthy subject; right panel: MCNS T cells from relapse