Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis

摘要

The expression level of circCSPP1 in DOX-resistant tissues and cells. a The expression level of circCSPP1 was detected by qRT-PCR in DOX-resistant or DOX-sensitive CRC tissues. b, c The DOX-resistant CRC LoVo/DOX (b) and HCT116/DOX (c) cells were analyzed by MTT assay. IC50 of 24 h was shown. d The expression of circCSPP1 was examined by qRT-PCR in LoVo/DOX and HCT116/DOX cells as well as in LoVo and HCT116 cells. *P < 0.05