Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple‐negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways

摘要

CERK is upregulated in TNBC patients. Scatter plot of CERK mRNA (a) and protein (b) in paired TNBC malignant tissues and adjacent normal tissues. Samples were obtained from 100 TNBC patients. The line shown in the scatter plot indicates the average expression of CERK in TNBC malignant and normal tissue. Average of CERK mRNA (c) and protein (d) ratios in the tumor and normal tissues of TNBC patients; *P < 0.05, compared with that in normal tissues