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A Five-in-One First-in-Human Study To Assess Safety Tolerability and Pharmacokinetics of RO7049389 an Inhibitor of Hepatitis B Virus Capsid Assembly after Single and Multiple Ascending Doses in Healthy Participants

机译：一项五联的一体化研究以评估RO7049389的安全性耐受性和药代动力学乙型肝炎病毒衣壳组装的抑制剂在健康参与者中单一和多个升序剂量之后

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Sheng Feng; Edward Gane; Christian Schwabe; Mingfen Zhu; Miriam Triyatni; Julian Zhou; Qingyan Bo; Yuyan Jin;
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作者单位

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年(卷),期 2020(64),11
年度 2020
页码 e01323-20
总页数 9
原文格式 PDF
正文语种
中图分类药学;微生物学;
关键词
RO7049389; first-in-human study; safety; pharmacokinetics; drug-drug interaction; first in human; hepatitis B virus;

机译：RO7049389;先进的研究;安全;药代动力学;药物 - 药物相互作用;首先在人体;乙型肝炎病毒;

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专利

1. Phase I, First-in-Human, Single and Multiple Ascending Dose- and Food-Effect Studies to Assess the Safety, Tolerability and Pharmacokinetics of a Novel Anti-hepatitis B Virus Drug, Bentysrepinine (Y101), in Healthy Chinese Subjects [J] . Clinical drug investigation . 2020,第6期

机译：第一期，第一，单一和多个上升剂量和食物效应研究，以评估新型抗乙型肝炎病毒药物，Bentysrepinine（Y101），在健康的中国受试者中的安全性，耐受性和药代动力学
2. A First-in-Human Trial of GLS4, a Novel Inhibitor of Hepatitis B Virus Capsid Assembly, following Single- and Multiple-Ascending-Oral-Dose Studies with or without Ritonavir in Healthy Adult Volunteers [J] . Zhao Nan, Jia Bo, Zhao Hong, Antimicrobial agents and chemotherapy. . 2020,第1期

机译：在具有或没有Ritonavir的健康成人志愿者中的单次和多次上升 - 口服 - 剂量研究
3. A First-in-Human Trial of GLS4, a Novel Inhibitor of Hepatitis B Virus Capsid Assembly, following Single- and Multiple-Ascending-Oral-Dose Studies with or without Ritonavir in Healthy Adult Volunteers [J] . Journal of neurosurgical sciences . 2020,第1期

机译：在具有或没有Ritonavir的健康成人志愿者中的单次和多次上升 - 口服 - 剂量研究
4. Pharmacokinetics and Tolerability of Sublingual Fentanyl in Healthy Japanese and Caucasian Volunteers: Phase I, Open-Label Single-Dose Study [C] . U. Lorch, F. Farrell, J. Kilborn, International Pain Clinic Congress . 2008

机译：健康日本和白种人志愿者舌下芬太尼的药代动力学和耐受性：I期，开放标签单剂量研究
5. A First-in-Human Trial of GLS4 a Novel Inhibitor of Hepatitis B Virus Capsid Assembly following Single- and Multiple-Ascending-Oral-Dose Studies with or without Ritonavir in Healthy Adult Volunteers [O] . Nan Zhao, Bo Jia, Hong Zhao, 2020

机译：在具有或没有RitonaviR的健康成人志愿者中的单一和多次上升 - 口服剂量研究之后GLS4的首次试验GLS4甲型肝炎病毒衣壳组装的新型抑制剂
6. A Five-in-One First-in-Human Study To Assess Safety, Tolerability, and Pharmacokinetics of RO7049389, an Inhibitor of Hepatitis B Virus Capsid Assembly, after Single and Multiple Ascending Doses in Healthy Participants [O] . Sheng Feng, Edward Gane, Christian Schwabe, 2020

机译：一项五联的一体化研究，以评估RO7049389的安全性，耐受性和药代动力学，乙型肝炎病毒衣壳组装的抑制剂，在健康参与者中单一和多个升序剂量之后

A Five-in-One First-in-Human Study To Assess Safety Tolerability and Pharmacokinetics of RO7049389 an Inhibitor of Hepatitis B Virus Capsid Assembly after Single and Multiple Ascending Doses in Healthy Participants

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