A 63-year-old White woman with gastroesophageal reflux disease, controlled with aggressive lifestyle interventions and high-dose proton pump inhibitors, underwent her first upper endoscopy to screen for Barrett's esophagus, which revealed numerous nonscrapable small yellowish plaques involving the middle and lower third of the esophagus diffusely (Figure (Figure1).1). Given the broad macroscopic differential diagnosis, these lesions were biopsied for histopathological characterization. The histopathological examination of these esophageal biopsies using hematoxylin and eosin stains revealed stratified squamous epithelium with multiple lobulated sebaceous glands without hair follicles in the lamina propria consistent with esophageal ectopic sebaceous glands (EESG; Figure Figure2).2). There was no evidence of intestinal metaplasia, candida, or viral cytopathic effect. The patient was counseled about this benign finding, and no changes were made to her established management plan.
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