Immunohistochemical Assessment of Immune Response in the Dermis of Sarcoptes scabiei—Infested Wild Carnivores (Wolf and Fox) and Ruminants (Chamois and Red Deer)

摘要

This article studies the local immune processes in dermis underlying the macroscopical differences (hyperkeratotic or alopecic) in mangy lesions from wolves ( ), foxes ( ), chamois ( ) and red deer ( ) naturally infested with . Skin sections were immuno-stained to detect macrophages, plasma cells, T lymphocytes and B lymphocytes. Skin lesions contained significantly more inflammatory cells in fox than in wolf and chamois. Macrophages were the most abundant inflammatory cells in the lesions of all the species studied, suggesting a predominantly innate, non-specific immune response. Lesions from wolf contained higher proportions of macrophages than the other species, which may reflect a more effective response, leading to alopecic lesions. Fox and chamois may also mount substantial humoral and cellular immune responses with apparently scarce effectiveness that lead to hyperkeratotic lesions.