Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

机译：结直肠癌患者初级和匹配转移组织之间的一致性或不间断的基因组谱的临床意义

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The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the clinical implication.

机译：本研究的目的是鉴定结直肠癌（CRC）患者中初级和匹配的转移性肿瘤之间的一致性或不间断的基因组分析，并探讨临床意义。

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期刊名称 Cancer Research and Treatment : Official Journal of Korean Cancer Association
作者
Jung Yoon Choi; Sunho Choi; Minhyeok Lee; Young Soo Park; Jae Sook Sung; Won Jin Chang; Ju Won Kim; Yoon Ji Choi; Jin Kim; Dong-Sik Kim; Sung-Ho Lee; Junhee Seok; Kyong Hwa Park; Seon Hahn Kim; Yeul Hong Kim;
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年(卷),期 2020(52),3
年度 2020
页码 -1
总页数 15
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Colorectal neoplasms; Genomics; Neoplasm metastasis; Principal component analysis; Survival;

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专利

1. Angiogenesis in primary colorectal cancer and matched metastatic tissues: Biological and clinical implications for anti-angiogenic therapies [J] . Oncology letters . 2020,第5期

机译：原发性结直肠癌和匹配转移组织中的血管生成：抗血管生成治疗的生物学和临床意义
2. Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: Evaluation of concordance between genomic and transcriptional profiles [J] . Vignot Stephane, Lefebvre Celine, Frampton Garrett M., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2015,第7期

机译：大肠癌患者原发肿瘤和匹配转移的比较分析：基因组和转录谱之间一致性的评估
3. Concordant KRAS mutations in primary and metastatic colorectal cancer tissue specimens: A meta-analysis and systematic review [J] . HanC.-B., LiF., MaJ.-T., Cancer investigation . 2012,第10期

机译：原发性和转移性结直肠癌组织标本中的一致KRAS突变：荟萃分析和系统评价
4. Single Cell Genomic Profiling of Circulating Tumor Cells (CTCs) from Metastatic Colorectal Cancer (mCRC) Identify Tumor Heterogeneity and Rare Somatic Driver Alterations [C] . Stephanie Greene, Angel Rodriguez, Jerry Lee, International Molecular Medicine Tri-Conference. . 2016

机译：转移结直肠癌（MCRC）的循环肿瘤细胞（CTC）的单细胞基因组分析识别肿瘤异质性和稀有躯体驾驶员改变
5. Comparing gene expression profiles of cell culture models with profiles of tumor xenografts and patient tumors: Implications for lung and breast cancers. [D] . Creighton, Chad J. 2006

机译：将细胞培养模型的基因表达谱与异种移植瘤和患者肿瘤谱进行比较：对肺癌和乳腺癌的影响。
6. Clinical Utility of Plasma KRAS NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients—The Importance of Tissue/Plasma Discordant Cases [O] . Vincenzo Formica, Jessica Lucchetti, Elena Doldo, 2021

机译：血浆KRANRAS和BRAF突变分析的临床效用与转移结直肠癌患者的实时PCR - 组织/血浆不和谐案件的重要性
7. Clinical Utility of Plasma KRAS, NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients—The Importance of Tissue/Plasma Discordant Cases [O] . Vincenzo Formica, Jessica Lucchetti, Elena Doldo, 2020

机译：血浆KRA，NRAS和BRAF突变分析的临床效用与转移结直肠癌患者的实时PCR - 组织/血浆不和谐案件的重要性

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

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