Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS

摘要

The timeline depicts MCZ treatment and assessments of cognitive functions of mice ( ). MCZ was injected intraperitoneally and LPS or saline was injected 2 h later MCZ injection, this schedule progressed daily for 7 days. After 7 days of injection, memory tests were conducted; the Morris water maze test was performed three times a day for 5 days. Escape latency ( ) and distance ( ) to arrive at the platform were automatically recorded. Data are expressed as the mean ± SEM (Two-way ANOVA for repeated measures followed by post-hoc Bonferroni,  ##  ###  $  $$  $$$  p p p d). Data are expressed as the mean ± SEM the passive avoidance test was performed 1 day after a learning trial test ( ). The total number of mice were 40 (control group;  = 8, MCZ group;  = 8, LPS group;  = 12 and MCZ + LPS group;  = 12). The mice were given an electric shock when they entered the dark compartment. Data are expressed as the mean ± SEM ( test,  ##  ###  $  $$  $$$  p p p