Chemical Composition Antioxidant Genotoxique and Antigenotoxic Potentials of Phlomis Bovei De Noé Aerial Parts.

摘要

In the present work, chemical investigation of the aerial parts of de Noé an endemic species from Algeria, led to the isolation and identification of seven known compounds including five flavones glycosides: Chrysoeriol 7- -(3’’-( et )- -coumaroyl)-β-glucoside , terniflorin (apigenin-7- -(6’’- -coumaroyl)glucoside) , apigenin-7- -(6’’-(5’’’-methoxy-coumaryl) glucoside , apigenin 7- -(3″- -coumaryl) , hispidulin-7- -glucuronide and two cinnamic acid derivatives: -coumaric acid methyl ester ( et ) , chlorogenic acid . Compound is described for the first time in the species de Noé, the genus and the family. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. Some pure compounds and extracts have been evaluated for their antioxidant activities through different methods: DPPH and ABTS assays as well as CUPRAC assay. Genotoxic and antigenotoxic activities of pure compounds were also evaluated on PQ37 cells by the SOS Chromotest.