The dose–response characteristics of four NTCP models: using a novel CT-based radiomic method to quantify radiation-induced lung density changes

摘要

Lung Segmentation and registration results: ( ) shows for a representative patient a treatment planning chest CT slice through a tumor located within the hilar region. The colorized overlay is the planned dose distribution over a 10 × 10 × 10 cm region centered on the isocenter. ( ) An axial CT slice at approximately the same anatomical location at the 8-month follow-up time point and in the same patient as ( ). ( ) Depicts the result of the rigid body registration of the 8-month follow-up CT to the panning CT at the same anatomical slice location. ( ) The lung volume mask in white and gray for the 8-month follow-up image. The computed dose grid is transformed from the planning CT image space to the follow-up CT image space and the gray pixels show where the dose grid aligns to pixels in the lung mask of the follow-up image. The region of gray pixels is where the dose–response data is computed.