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Comparison of a commercially available oral nutritional supplement and intravenous fluid therapy for dehydration in dairy calves

机译:乳牛脱水的市售口服营养补充剂和静脉输液疗法的比较

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摘要

Calf scours is a primary cause of morbidity and mortality in the dairy industry. Effective treatments are needed to minimize death, maximize welfare, and maintain growth and productivity. The objective of this trial was to compare the efficacy of a commercially available nutritional supplement (Diaque, Boehringer-Ingelheim Vetmedica Inc., St. Joseph, MO) and i.v. lactated Ringer's solution (LRS) in rehydrating, preventing acidemia, and correcting electrolyte imbalances in an experimental model for calf scours. Twenty-four colostrum-fed suckling dairy calves were used in a modified crossover design. An osmotic diarrhea was induced by orally feeding commercial milk replacer modified with high level of sucrose to create a hypertonic milk solution, and administering oral hydrochlorothiazide and spironolactone for 48 h. The intention was to create a challenge sufficient to result in moderately dehydrated, standing calves without producing severe depression or loss of suckle. The efficacy of i.v. fluid therapy and a commercial nutritional supplement were subsequently compared for reversing the effects of the diarrheal disease. Treatment A consisted of administering the nutritional supplement according to label directions (100 g in 1.9 L of warm water, 3 times a day), and treatment B consisted of i.v. LRS (2 L, once a day). Clinical signs and laboratory results were obtained once daily by a blinded observer. The induction method was effective in creating the desired effect, as demonstrated by weight loss and subjective health and hydration scores. Both treatment groups experienced increases in body weight, base excess, and bicarbonate, and decreases in total protein and packed cell volume following treatment. Both i.v. LRS and Diaque are effective methods to correct hypovolemia and control derangements in acid-base status in calves with diarrhea and dehydration.
机译:小牛冲刷是乳品行业发病率和死亡率的主要原因。需要有效的治疗方法以最大程度地减少死亡,最大程度的福利并保持增长和生产力。该试验的目的是比较市售营养补充剂(Diaque,Boehringer-Ingelheim Vetmedica Inc.,圣约瑟夫,密苏里州)和i.v.乳酸林格氏液(LRS)在补水,预防酸血症和纠正小牛痢疾的实验模型中的电解质失衡方面具有重要意义。在改良的交叉设计中使用了二十四头初乳喂养的乳牛犊。通过口服喂食用高水平蔗糖修饰的商业代乳品以产生高渗牛奶溶液,并口服氢氯噻嗪和螺内酯48 h,可引起渗透性腹泻。目的是要提出一个足以导致中等脱水,站立的犊牛而不会引起严重的压抑或乳汁流失的挑战。 i.v.的功效随后比较了液体疗法和商业营养补品,以逆转腹泻病的影响。处理A包括按照标签说明服用营养补充剂(在1.9 L的温水中100 g,每天3次),而处理B则由i.v. LRS(2 L,每天一次)。盲人观察员每天获得一次临床体征和实验室结果。如减肥,主观健康和水化分数所证明,诱导方法可有效产生所需效果。两个治疗组在治疗后均出现体重增加,碱过剩和碳酸氢盐增加,总蛋白和填充细胞体积减少。双方LRS和Diaque是纠正腹泻和脱水犊牛血容量不足和控制酸碱状态紊乱的有效方法。

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