Regulatory effects of bone morphogenetic protein‐4 on tumour necrosis factor‐α‐suppressed Runx2 and osteoprotegerin expression in cementoblasts

摘要

Root resorption is a common phenomenon presented in periodontitis and orthodontic treatment, both of which are accompanied by an elevated ‐α expression level in the periodontal tissues. Previously, we proved that ‐α showed an inhibitory effect on cementoblast differentiation, mineralization and proliferation. However, the effect of ‐α on Runx2 and osteoprotegerin ( ) expression remains undetermined. This study aimed to identify the influence of ‐α on Runx2 and expression in cementoblasts and to test whether ‐2,‐4,‐6,‐7 would affect ‐α‐regulated Runx2 and .