Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells

摘要

Ligand-bound cell surface cytokine receptors are internalized, then either returned to the surface or transferred to lysosomes. The rates of internalization and recycling may vary depending on cell types, ligands, or the environment, and affect cell proliferation, survival, or function. However, the detailed kinetics of this process, particularly in hematopoietic cells, are largely unknown.