Rotator cuff tear (RCT) is a representative muscle-tendinous disease-causing shoulder pain ( ), and recently, its prevalence rate is remarkably increasing by an aging population and various sports activities ( , ). For RCTs, surgical repair is prevalent and has been a commonly accepted treatment, especially when the conservative management was failed ( ). Nevertheless, failure of rotator cuff healing after repair is common and is one of major post-surgical complications ( ), though the arthroscopic repair techniques have been advancing steadily. Most of all, fatty degeneration in muscle is a critical detrimental cause of poor functional outcome due to its irreversible property ( , ). Although the precise mechanisms of muscle fatty infiltration are not fully determined yet, numbers of studies have assumed that muscle fat accumulation is caused by adipogenic differentiation of the stem cells in muscle ( - ).
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