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Fast and accurate correction of optical mapping data via spaced seeds

机译:通过间隔种子快速准确地校正光学映射数据

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摘要

Optical mapping data is used in many core genomics applications, including structural variation detection, scaffolding assembled contigs and mis-assembly detection. However, the pervasiveness of spurious and deleted cut sites in the raw data, which are called Rmaps, make assembly and alignment of them challenging. Although there exists another method to error correct Rmap data, named cOMet, it is unable to scale to even moderately large sized genomes. The challenge faced in error correction is in determining pairs of Rmaps that originate from the same region of the same genome.
机译:光学测绘数据用于许多核心基因组学应用程序,包括结构变异检测,脚手架组装重叠群和错配检测。但是,原始数据中伪造和删除的剪切位点的普遍性(称为Rmap)使它们的组装和对齐面临挑战。尽管存在另一种错误校正Rmap数据的方法,称为cOMet,但它甚至无法扩展到中等大小的基因组。纠错面临的挑战是确定源自同一基因组同一区域的Rmap对。

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