A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons

摘要

Timeline and sequence of tests performed on mice and age at testing ( ). There were no genotypic differences in either running wheel activity on each day over first 28 days ( ) or in total over first 28 days  = 10 WT,  = 10 mice ( ). Locomotor activity (total distance, ) and movement speed ( ) during the 20-minute open field test. Locomotor activity (arm entries) during the 5-minute Y-maze test of spontaneous alternations ( ). Corner visits ( ), nosepokes ( ) and % corner visits with nosepokes (NPs) ( ) during the first hour of habituation to the novel IntelliCage® environment. Nosepokes ( ) and corner visits ( ) during the first 24 h of habituation to the IntelliCage®. *  p Aspm mice.  Aspm mice independent of exercise experience). Data are means ± SEM. WT = wildtype control mice, RW = running wheel, PV + = parvalbumin +, rev = wheel revolutions.