Pro-neurogenic effect of fluoxetine in the olfactory bulb is concomitant to improvements in social memory and depressive-like behavior of socially isolated mice

摘要

Female mice were maintained in groups (control) or isolated (social isolation) during 7 days. Thereafter, animals were submitted to social recognition test for short (STM) and long-term memory (LTM) as well as forced-swimming test (FST). Both groups presented STM and LTM, and no difference between groups were detected. SI increased immobility in female mice (***  e Male mice were maintained in groups (control) or isolated (social isolation) during 7 days. At day 8, animals received a single injection of saline (SAL), fluoxetine (FLX), or desipramine (DES) and 20 min after were exposed to forced-swimming test (FST). Male mice presented an increase in immobility (depressive-like behavior) after social isolation (  p p p g Male mice presented an increase in immobility (depressive-like behavior) after social isolation (  p p h Male mice were maintained in groups (control) or isolated (social isolation) during 7 days. At day 8, animals received a single injection of SAL, FLX, or DES and 20 min after were exposed to the training session of the social recognition test. Twenty-four hours later, the social memory was tested. Results are presented as social recognition index [time exploring the juvenile during TT/time exploring the juvenile during TR + TT]. SI mice differ from control (  j Male mice were maintained in groups (control) or isolated (social isolation) during 7 days. Every day, animals received a single injection of SAL, FLX, or DES. At day 8, the training session of the social recognition test was performed. Twenty-four hours later, the social memory was tested. Results are presented as social recognition index [time exploring the juvenile during TT/time exploring the juvenile during TR + TT]. SI mice differ from control (  p