On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D2/3 receptor agonist radioligand study

摘要

Upper panel: AMPH-induced DA release in five subdivisions of the basal ganglia (CAU Caudate, PUT Putamen, VST Ventral Striatum, GP Globus Pallidus, SNVTA substantia nigra/ventral-tegmental area) in healthy volunteers before (HV ; sky-blue) and after prospective sensitization to AMPH (HV ; deep-blue), and in antipsychotic-naïve patients FEP (red). Patients show larger AMPH-induced DA release than HV . Prospective sensitization of HV induced by repeated AMPH administration amplifies DA release, such that the AMPH response in HV no longer differs from FEP. Statistical parametric maps displaying brain areas with the largest sensitization-induced increases in DA-release. Peak effects (up to 60 percent increase) are found in VST (MNI coordinates  = −19,  = −16,  = −10). Subjective AMPH effects in HV undergoing prospective sensitization to AMPH. Repeated administration (four times; light to deep-blue) of AMPH at low constant dose (0.3 mg/kg body weight) successfully induced sensitization as shown by the progressive increase in the AMPH response. Patients with FEP (red; one administration of AMPH) displayed marked AMPH effects already at first contact with the drug. SSQ Subjective States Questionnaire; MNI Montreal Neurologic Institute standard space; bars represent mean ± standard error of the mean; post-hoc two-tailed -tests: *  p