S85. INDIVIDUALS WITH POSITIVE AND NEGATIVE SCHIZOTYPY EXHIBIT A REVERSED PATTERN OF THALAMIC-CEREBELLAR BRAIN CONNECTIVITY

摘要

The cerebellum is structurally and functionally connected with the cerebral cortex and limbic circuits and plays an important role in high level cognitive functions. Abnormalities of cerebellar connections have been observed in clinical samples including autism and schizophrenia. Increased volumes of lateral ventricle and pallidum together with a reduction in hippocampus, amygdala, thalamus, accumbens and intracranial volumes have been found in large-scale analyses of schizophrenia patients from the ENIGMA schizophrenia Working Group (van Erp et al., 2016). Reduction of total cerebellar grey matter volume in schizophrenia patients was also observed in a multisite mega-analysis (Moberget et al., 2017). In the present study we aimed to investigate the subcortical volumes and cerebellar grey matter volumes, as well as their structural covariance in individuals with schizotypy.