10.4 MAPPING NEURO-BEHAVIORAL RELATIONSHIPS IN DIMENSIONAL GEOMETRIC EMBEDDING (N-BRIDGE) VIA PHARMACOLOGY COMPUTATION AND CLINICAL NEUROIMAGING: UNIFYING CATEGORIES AND DIMENSIONS ALONG THE PSYCHOSIS SPECTRUM

摘要

A key challenge in the field of neuropsychiatry lies in matching patients with effective treatments. Most studies in psychiatry operate under the canonical assumption that categorical diagnostic clinical grouping and/or pre-existing clinical assessments are the ‘gold standard’ for describing behavioral - and therefore neural - variation in patients. Attempts to robustly characterize the neural substrates of these predefined variables have yielded limited success, suggesting an inadequate mapping to neurobiologically meaningful variation. Notably, a great deal of heterogeneity exists even within groups of patients with the same categorical diagnosis. Thus, understanding the mapping between specific behaviors and clinically-meaningful variation in neural properties is critical to develop and ultimately administer effective individualized neurobehavioral treatments.