Therapeutic influences of almond oil on male rats exposed to a sublethal concentration of lead

摘要

Globally, human exposure to heavy metals has risen dramatically. Lead (Pb) is one of the most toxic heavy metals to human and other living organisms. Pb affects certain biochemical and physiological activities of the body. Many scientific investigations have documented the therapeutic and antioxidant properties of natural products which isolated from plant sources. The present study was therefore undertaken to evaluate the therapeutic influence of almond oil against Pb toxicity in male rats. The experimental rats were distributed into four groups. The first group was served as control. The second group was treated with 100 mg/kg body weight of Pb. The third group was subjected to almond oil (800 mg/kg body weight) and Pb. The fourth group was supplemented with almond oil. After six weeks, blood serum specimens were analyzed. In the second group, Pb produced a marked increase of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total bilirubin, glucose, triglycerides, low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), creatine kinase (CK), lactate dehydrogenase (LDH), creatinine, blood urea nitrogen (BUN), uric acid and malondialdehyde (MDA) levels, while the levels of total protein, albumin, high density lipoprotein cholesterol (HDL-C), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were significantly decreased. In contrast, the treatment with almond oil notably improved the biochemical changes and showed antioxidative effect. The present study disclosed the therapeutic influence of almond oil on the basis of its antioxidant effect against Pb toxicity. Moreover, these new findings indicated that the constituents of almond oil have a promising significant potential in biomedical and pharmacological studies.