Electrospinning and Post-Spun Chain Conformations of Synthetic Hydrophobic Poly(α-amino acid)s

摘要

Electrospinning and post-spun conformations of hydrophobic poly( -amino acid)s are described in this study. The poly( -amino acid)s, poly(Gly), poly( -Ala), poly( -Val), and poly( -Leu) were synthesized via corresponding -carboxy- -amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by -terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly( -amino acid)s were electrospun from trifluoroacetic acid or trifluoroacetic acid/dichloromethane solutions. The FT-IR spectroscopy and wide-angle X-ray diffraction indicated that the electrospun poly( -Ala) and poly( -Leu) fibers predominantly adopts -helical structure, whereas poly( -Val) and poly(Gly) fibers exhibited mainly -strand and random coil structures, respectively.