Targeting oncogenic SOX2 in human cancer cells: therapeutic application

摘要

. SOX2 (cicada) is a transcriptional downstream target of MSX2 (mantis). Upon binding to SOX2 gene promoter, MSX2 negatively controls SOX2 transcription. MSX2, on the other hand, is a substrate of FBXW2 (oriole) E3 ligase. Upon hypoxia, FBXW2 binds to MSX2 and targets it for ubiquitylation and subsequent degradation. By inactivating FBXW2, MLN4924 (man with a slingshot) causes MSX2 accumulation to transcriptionally repress SOX2