Analysis of VISTA expression and function in renal cell carcinoma highlights VISTA as a potential target for immunotherapy

摘要

. (A) Immunofluorescence analyses demonstrating the expression of VISTA, PD-L1, B7-H3 and B7S1 together with DAPI and CD45 in paired tumors and para-tumors. (B) Quantifications of VISTA, PD-L1, B7-H3 and B7S1 by immunofluorescence staining were shown ( = 47). ** < 0.01. (C) Immunofluorescence analyses demonstrating VISTA expression on tumor cells. (D and E) Representative figures and summarized data showing percentage of VISTA cells in mDCs, monocytes/macrophages, monocytic MDSCs from PBMC, para-tumors and tumors of ccRCC patients ( = 53). * < 0.05