Mechanisms of lung toxicity induced by biomass burning aerosols

摘要

Inflammatory responses in mice following exposure to aerosols generated from water-soluble wood tar extract. Mice were exposed to wood tar solution-generated particles using an individual single exposure model. For each exposure, the initial concentration of the water-soluble extract from wood tar was 2 mg/ml or 10 mg/ml. Aerosols were generated via nebulization of these solutions and directed to six mice for each of the concentrations tested (  = 6). Lipopolysaccharide (LPS) was used as a positive control (  = 4). PBS was used as the negative control. Total cell number in BALF and total cell number in lung tissue. Further verification of the different populations was performed by flow cytometry of the collected cells stained with different markers. Neutrophil percentage. Macrophage percentage. Monocyte percentage. The data are expressed as the mean ± SEM. Means marked with different letters are significantly different from each other at