Longitudinal Analysis of the Choriocapillaris Using Optical Coherence Tomography Angiography Reveals Subretinal Fluid as a Substantial Confounder in Patients with Acute Central Serous Chorioretinopathy

摘要

A decrease in subretinal fluid is associated with a reduction in OCTA choriocapillaris alteration. Representative retinal thickness heat maps (top row) and OCTA images of the choriocapillaris (CC) without and with flow pseudo-coloration (middle rows) and OCTA segmentation (bottom row) in patients with acute central serous chorioretinopathy (CSC) demonstrating decreasing ( , ) or increasing ( , ) subretinal fluid (SRF) at follow-up (FU) examination compared with baseline. Decreased flow signal from the CC is illustrated with green pixels, increased flow signal with red pixels. , The SRF spontaneously absorbed at FU examination, which is associated with a reduction in decreased CC OCTA flow signal. , SRF at FU examination is markedly increased, which is associated with a decrease in CC OCTA flow signal. , Retinal thickness differences between baseline and follow-up (∆RT in µm) correlate with increasing or decreasing flow signal (presented in % of total area). Each dot represents one eye. rho = Spearman’s