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Impact of Baseline Nutrition and Exercise Status on Toxicity and Outcomes in Phase I and II Oncology Clinical Trial Participants

机译：基线营养和运动状态对一期和二期肿瘤临床试验参与者的毒性和结果的影响

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摘要

Malnutrition and physical inactivity are common in patients with advanced cancer and are associated with poor outcomes. There are increasing data that altered body composition is related to the pharmacokinetic properties of cancer therapies. These adverse conditions may impact outcomes in early‐phase oncology clinical trials.

机译：营养不良和缺乏体育锻炼在晚期癌症患者中很常见，并且与不良预后相关。越来越多的数据表明，改变的身体成分与癌症疗法的药代动力学特性有关。这些不利条件可能会影响早期肿瘤临床试验的结果。

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期刊名称 The Oncologist
作者
Rishi Jain; Elizabeth Handorf; Vipin Khare; Matthew Blau; Yana Chertock; Michael J. Hall;
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作者单位

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年(卷),期 2020(25),2
年度 2020
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Malnutrition; Cachexia; Exercise; Toxicity; Outcomes;

机译：营养不良;恶病质;运动;毒性;结果;

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专利

1. Impact of Baseline Nutrition and Exercise Status on Toxicity and Outcomes in Phase I and II Oncology Clinical Trial Participants [J] . Jain Rishi, Handorf Elizabeth, Khare Vipin, The oncologist . 2020,第2期

机译：基线营养和行使地位对II和II型肿瘤临床试验参与者毒性和结果的影响
2. Impact of Baseline Nutrition and Exercise Status on Toxicity and Outcomes in Phase I and II Oncology Clinical Trial Participants [J] . Rishi Jain, Elizabeth Handorf, Vipin Khare, The oncologist . 2020,第2期

机译：基线营养和行使地位对II和II型肿瘤临床试验参与者毒性和结果的影响
3. Virological outcomes of EVG/COBI/FTC/TDF and EVG/COBI/FTC/TAF in antiretroviral-naive HIV-1-infected participants with baseline HIV-1 RNA ≥1,000,000 copies/ml: a post hoc analysis of Phase III clinical trials. [J] . Paul Sax, Edwin DeJesus, David Wohl, Antiviral therapy . 2018,第1期

机译：EVG / COBI / FTC / TDF和EVG / COBI / FTC / FTC / TAF在抗替代病毒 - 幼稚HIV-1感染参与者的病毒学结果，基线HIV-1 RNA≥1,000,000拷贝/ mL：III期临床试验的后HOC分析。
4. Combining Dosimetry Toxicity: Analysis of two UK Phase III Clinical trials [C] . Sarah L Gulliford ICCR . 2014

机译：结合剂量测定和毒性：两个英国第三期临床试验分析
5. Examination of novel statistical designs for phase II and phase III clinical trials. [D] . Ayanlowo, Ayanbola Olajumoke. 2007

机译：检验II期和III期临床试验的新颖统计设计。
6. Impact of ultrahigh baseline PSA levels on biochemical and clinical outcomes in two Radiation Therapy Oncology Group prostate clinical trials [O] . George Rodrigues, Kyounghwa Bae, Mack Roach, -1

机译：超高基线PSA水平对两种放射治疗肿瘤术语前列腺临床试验中的生物化学和临床结果的影响
7. HG-41OUTCOMES FOR PATIENTS WITH RECURRENT MALIGNANT GLIOMA ENROLLED ON PHASE II CLINICAL TRIALS: AN ANALYSIS OF CONTEMPORARY CHILDREN'S ONCOLOGY GROUP (COG) AND PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) TRIALS [O] . Eugene Hwang, Catherine Billups, Arzu Onar-Thomas, 2016

机译：患有反复性恶性胶质瘤患者的HG-41outcomes患有II期临床试验：当代儿童肿瘤组（COG）和小儿脑肿瘤联盟（PBTC）试验分析

Impact of Baseline Nutrition and Exercise Status on Toxicity and Outcomes in Phase I and II Oncology Clinical Trial Participants

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