Altered anticipation and processing of aversive interoceptive experience among women remitted from bulimia nervosa

摘要

Experimental paradigm. The inspiratory breathing load paradigm has been used to study aversive interoception in healthy and psychiatric populations [ , – ]. During fMRI scanning, participants wore a nose clip and were instructed to breathe through a hose that intermittently restricted breathing for 40-s periods via 40 cm H20/L/sec inspiratory loads. Colored rectangles (mean duration 6 s) signaled the likelihood of an upcoming breathing load period (yellow = 25% chance of subsequent breathing load, blue = 0% chance). Overlaid on each rectangle, an arrow pointing left or right cued participants to press a left button or a right button, respectively. Accuracy and reaction time on this continuous performance task measured attention. The post-load period after all breathing load conditions lasted an average of 2 s