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HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3

机译：通过降低HA的稳定性来确定H5N1和H7N9流感病毒对人内皮细胞的HA依赖取向这使HA可以应对无效的内体酸化和组成性表达的IFITM3

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期刊名称 Journal of Virology
作者
Luca Hensen; Tatyana Matrosovich; Katrin Roth; Hans-Dieter Klenk; Mikhail Matrosovich;
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作者单位

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年(卷),期 2020(94),1
年度 2020
页码 -1
总页数 19
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
IFITM; endothelial; fusion; hemagglutinin; influenza; stability; tropism;

机译：IFITM;内皮;融合;血凝素;流行性感冒;稳定性;嗜性;

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专利

1. Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections [J] . N. Komadina, S. G. Sullivan, K. Kedzierska, Epidemiology and infection . 2019,第15期

机译：事先接触人类甲型流感病毒中发现的免疫原性肽可能会影响禽流感H5N1和H7N9病毒感染病例的年龄分布
2. Influenza Viral Vectors Expressing Two Kinds of HA Proteins as Bivalent Vaccine Against Highly Pathogenic Avian Influenza Viruses of Clade 2.3.4.4 H5 and H7N9 [J] . Jinping Li, Guangyu Hou, Yan Wang, Frontiers in Microbiology . 2018,第6期

机译：流感病毒载体表达两种HA蛋白作为针对进化枝2.3.4.4 H5和H7N9的高致病性禽流感病毒的二价疫苗
3. Influenza Viral Vectors Expressing Two Kinds of HA Proteins as Bivalent Vaccine Against Highly Pathogenic Avian Influenza Viruses of Clade 2.3.4.4 H5 and H7N9 [J] . Jinping Li, Guangyu Hou, Yan Wang, Frontiers in Microbiology . 2018,第6期

机译：流感病毒载体表达两种HA蛋白作为针对进化枝2.3.4.4 H5和H7N9的高致病性禽流感病毒的二价疫苗
4. Replication of neurovirulent and non-neurovirulent human H1N1 influenza A viruses in mouse brain and nerve cell cultures: Virus strain-specific and host cell-dependent variations in progeny virus assembly,mRNA splicing efficiency, and expression of RNA gene segments 7 and 8 [D] . Husak, Paul James 1994

机译：在鼠脑和神经细胞培养物中复制神经毒力和非神经毒力的人类甲型H1N1流感病毒：子代病毒装配，mRNA剪接效率以及RNA基因片段7和8的表达中病毒株特异性和宿主细胞依赖性变异
5. Constitutively Expressed IFITM3 Protein in Human Endothelial Cells Poses an Early Infection Block to Human Influenza Viruses [O] . Xiangjie Sun, Hui Zeng, Amrita Kumar, 2016

机译：在人内皮细胞中组成型表达的IFITM3蛋白对人流感病毒构成早期感染块
6. HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA, Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3 [O] . Luca Hensen, Tatyana Matrosovich, Katrin Roth, 2019

机译：通过降低HA的稳定性确定H5N1和H7N9流感病毒的H8-依赖性的对抗对人类内皮细胞的热感，这使得病毒应对效率低下的内体酸化并组成思考的IFITM3

HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3

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