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Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

机译：大肠癌类器官的免疫肽组学显示HLA I类新抗原稀疏且干扰素或MEK抑制剂治疗的新抗原没有增加

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摘要

Clinical characteristics of donor and mutation load in the 5 PDOs

机译：5个PDO中供体的临床特征和突变负荷

著录项

期刊名称 Journal for Immunotherapy of Cancer
作者
Alice Newey; Beatrice Griffiths; Justine Michaux; Hui Song Pak; Brian J. Stevenson; Andrew Woolston; Maria Semiannikova; Georgia Spain; Louise J. Barber; Nik Matthews; Sheela Rao; David Watkins; Ian Chau; George Coukos; Julien Racle; David Gfeller; Naureen Starling; David Cunningham; Michal Bassani-Sternberg; Marco Gerlinger;
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年(卷),期 2019(7),-1
年度 2019
页码 -1
总页数 15
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Patient derived organoids; Colorectal cancer; Neoantigens; Immunogenicity; Human leukocyte antigen; Antigen presentation; Immunotherapy; Mass spectrometry;

机译：患者来源的类器官;大肠癌;新抗原;免疫原性;人白细胞抗原;抗原呈递;免疫疗法;质谱法;

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专利

1. Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment [J] . Alice Newey, Beatrice Griffiths, Justine Michaux, Journal for ImmunoTherapy of Cancer . 2019,第1期

机译：大肠癌类器官的免疫肽组学显示HLA I类新抗原稀疏，且干扰素或MEK抑制剂治疗的新抗原没有增加
2. Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment [J] . Alice Newey, Beatrice Griffiths, Justine Michaux, Journal for ImmunoTherapy of Cancer . 2019,第1期

机译：大肠癌类器官的免疫肽组学显示HLA I类新抗原稀疏，且干扰素或MEK抑制剂治疗的新抗原没有增加
3. P01.02?HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer [J] . YW Asmann, Y Ren, DP Wickland, Journal for ImmunoTherapy of Cancer . 2020,第Suppla2期

机译：p01.02？HLA类-I和II类受限制的新宿老原载荷预测乳腺癌的整体存活
4. Enrichment and Identification of HLA-Associated Phosphopeptide Neoantigens from Hepatocellular Carcinoma for the Development of Novel Cancer Immunotherapeutics [C] . Paisley T Myers, Nico Buttner, Jennifer G. Abelin, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：从肝细胞癌中富集和鉴定HLA相关的磷酸肽新抗原以进行新型癌症免疫治疗
5. HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer [O] . Yingxue Ren, Yesesri Cherukuri, Daniel P. Wickland, 2020

机译：HLA I类和II类限制的新抗原负荷可预测乳腺癌的总体存活率
6. Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch-repair-deficient colorectal cancer tissue [O] . Tomomi Hirama, Serina Tokita, Munehide Nakatsugawa, 2021

机译：不匹配修复缺陷性结直肠癌组织中免疫原性HLA I类NeoAntigen的蛋白质组织鉴定

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

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