The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade

摘要

HOTAIR and ST6GAL1 are upregulated during CRC progression. Differential HOTAIR expression was detected between CRC tissues and the corresponding non-tumor tissues. High HOTAIR level was determined in advanced CRC stages. Overexpressed HOTAIR was identified in CRC patients with metastasis. HOTAIR expression was also identified in CRC cell lines by qRT-PCR. Upregulation of ST6GAL1 was detected in CRC tissues. ST6GAL1 expression was higher in advanced CRC patients. High ST6GAL1 expression was shown in CRC samples with metastasis. ST6GAL1 level was detected of CRC cell lines by qRT-PCR. ST6GAL1 expression was also identified in CRC cell lines by western blot. The Kaplan-Meier overall survival curves (OS) was illustrated on the basis of HOTAIR and ST6GAL1 expression. Data were the means ± SD of triplicate determinants (*