Skin Sensitization Study of Honey Bee (Apis mellifera) and Yellow Jacket (Vespula sp.) Venom on Rabbits

摘要

Bee venom is a special and exceptional defensive weapon in the animal world. Bee venom is also the first and most important defense to defend the bee colony. Bee venom is a different combination of widest variety of chemical substances that protect the bees against a wide range of enemies ( ). The most important allergen in bee venom composition is phospholipase A2, which is a glycoprotein with 134 amino acid residues ( ). The main and great allergens in vespid venoms are phospholipase A1 (Ves v 1), hyaluronidase (Ves v 2), and antigen 5 (Ves v 5). Phospholipase A1 include 6–14% of the total dry weight of vespid venom ( ). Antigen 5, is a considerable allergen in all vespid venoms ( ). Skin sensitization potential plays an important part of any toxicology program for new consumer products ( ).