首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Effects of Orally Administered Resveratrol on TNF IL-1β Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective Randomized Double-Blinded Placebo-Controlled Study
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Effects of Orally Administered Resveratrol on TNF IL-1β Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective Randomized Double-Blinded Placebo-Controlled Study

机译:口服白藜芦醇对马中TNFIL-1β白细胞吞噬活性和氧化爆发功能的影响:一项前瞻性随机双盲安慰剂对照研究

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摘要

Resveratrol, a phytophenol, is a commonly used equine nutraceutical supplement touted to exert anti-inflammatory effects. The effect of orally administered resveratrol on tumor necrosis factor (TNF), interleukin-1β (IL-1β), leukocyte phagocytic activity or oxidative burst function have not been reported in horses. The objective of this study was to determine the effects of a commercially available, orally administered resveratrol product on innate immune functions in healthy adult horses. Whole blood was collected from 12 horses prior to and following 3 weeks of treatment with either the manufacturer’s recommended dose of resveratrol or placebo. Phagocytosis, oxidative burst and pathogen associated molecular pattern (PAMP) motif-stimulated leukocyte production of TNF and IL-1β were compared pre- and post-treatment between treatment groups. Phagocytosis and oxidative burst capacity were evaluated via flow cytometry. Tumor necrosis factor and IL-1β were measured using cytotoxicity and ELISA assays, respectively. There were no significant differences in phagocytosis, oxidative burst or stimulated TNF or IL-1β production between resveratrol and placebo treatment groups. Orally administered resveratrol at a routinely recommended dose for a duration of 3 weeks did not significantly affect phagocytic activity, oxidative burst function or PAMP-stimulated leukocyte cytokine production.
机译:白藜芦醇,一种植物苯酚,是一种常用的马保健品,被吹捧成具有抗炎作用。尚未在马中报告口服白藜芦醇对肿瘤坏死因子(TNF),白介素1β(IL-1β),白细胞吞噬活性或氧化爆发功能的影响。这项研究的目的是确定市售的口服白藜芦醇产品对健康成年马的先天免疫功能的影响。在制造商建议的剂量白藜芦醇或安慰剂治疗3周之前和之后,从12匹马中采集全血。在治疗组之间比较了吞噬作用,氧化爆发和病原体相关分子模式(PAMP)基序刺激的TNF和IL-1β白细胞产生。通过流式细胞术评估吞噬作用和氧化爆发能力。分别使用细胞毒性和ELISA测定法测量肿瘤坏死因子和IL-1β。白藜芦醇和安慰剂治疗组之间在吞噬作用,氧化爆发或刺激的TNF或IL-1β产生方面无显着差异。以常规推荐剂量连续3周口服白藜芦醇对吞噬活性,氧化爆发功能或PAMP刺激的白细胞细胞因子产生没有明显影响。

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